Pneumonitis and multiple pneumonial infections under combined immune‐checkpoint inhibition

Large Deflection Analysis of Compliant Beams of Variable Thickness and Non-Homogenous Material under Combined Load and Multiple Boundary Conditions

This paper studies a new approach to analyze the large deflection behavior of prismatic and non-prismatic beams of non-homogenous material under combined load and multiple boundary conditions. The mathematical formulation has been derived which led to a set of six first-order ordinary differential equations. The geometric nonlinearity was solved numerically using the multiple shooting method co...

Superficial multiple fibromatosis( combined 3 syndromes)

A 50 years old male patient to referred to our clinic for multiple hard diffused lesions on palms, plantars and penis. The Genesis of the problem goes back to 10 years earlier. The lesions appeared first on the soles and gradually new lesions appeared on the palms and eventually on the penis, so that stretching and contraction of the fingers and toes has become painful. During the last 6 years,...

osteogenic inhibition in multiple myeloma

objective: multiple myeloma (mm) is a plasma cell malignancy where plasma cells are increased in the bone marrow (bm) and usually do not enter peripheral blood, but produce harmful factors creating problems in these patients (e.g. malignant plasma cells over activate osteoclasts and inhibit osteoblasts with factors like rankl and dkk). these factors are a main cause of bone lesion in mm patient...

Combined MTOR and autophagy inhibition

PI3K/Akt/mTOR and CDK4 combined inhibition enhanced apoptosis of thyroid cancer cell lines

Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...